Publications
C
Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.,
Kang, Yanyong, Kuybeda Oleg, de Waal Parker W., Mukherjee Somnath, Van Eps Ned, Dutka Przemyslaw, X Zhou Edward, Bartesaghi Alberto, Erramilli Satchal, Morizumi Takefumi, et al.
, Nature, 2018 06, Volume 558, Issue 7711, p.553-558, (2018)
D
Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.,
Bloch, Joël S., Mukherjee Somnath, Kowal Julia, Filippova Ekaterina V., Niederer Martina, Pardon Els, Steyaert Jan, Kossiakoff Anthony A., and Locher Kaspar P.
, Proc Natl Acad Sci U S A, 2021 Nov 23, Volume 118, Issue 47, (2021)
Development of "Plug and Play" Fiducial Marks for Structural Studies of GPCR Signaling Complexes by Single-Particle Cryo-EM.,
Dutka, Przemyslaw, Mukherjee Somnath, Gao Xiang, Kang Yanyong, de Waal Parker W., Wang Lei, Zhuang Youwen, Melcher Karsten, Zhang Cheng, H Xu Eric, et al.
, Structure, 2019 12 03, Volume 27, Issue 12, p.1862-1874.e7, (2019)
E
Engineered synthetic antibodies as probes to quantify the energetic contributions of ligand binding to conformational changes in proteins.,
Mukherjee, Somnath, Griffin Dionne H., Horn James R., Rizk Shahir S., Nocula-Lugowska Malgorzata, Malmqvist Magnus, Kim Sangwoo S., and Kossiakoff Anthony A.
, J Biol Chem, 2018 02 23, Volume 293, Issue 8, p.2815-2828, (2018)
S
Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.,
Kern, David M., Bleier Julia, Mukherjee Somnath, Hill Jennifer M., Kossiakoff Anthony A., Isacoff Ehud Y., and Brohawn Stephen G.
, Nat Struct Mol Biol, 2023 Mar 16, (2023)
Structure of an AMPK complex in an inactive, ATP-bound state.,
Yan, Yan, Mukherjee Somnath, Harikumar Kaleeckal G., Strutzenberg Timothy S., X Zhou Edward, Suino-Powell Kelly, Xu Ting-Hai, Sheldon Ryan D., Lamp Jared, Brunzelle Joseph S., et al.
, Science, 2021 Jul 23, Volume 373, Issue 6553, p.413-419, (2021)
Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling.,
Tsutsumi, Naotaka, Mukherjee Somnath, Waghray Deepa, Janda Claudia Y., Jude Kevin M., Miao Yi, Burg John S., Aduri Nanda Gowtham, Kossiakoff Anthony A., Gati Cornelius, et al.
, Elife, August 7 2020, Volume 9, (2020)
Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver.,
Liu, Hongtao, Irobalieva Rossitza N., Bang-Sørensen Rose, Nosol Kamil, Mukherjee Somnath, Agrawal Parth, Stieger Bruno, Kossiakoff Anthony A., and Locher Kaspar P.
, Cell Res, 2022 Aug, Volume 32, Issue 8, p.773-776, (2022)
Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase.,
Bloch, Joël S., John Alan, Mao Runyu, Mukherjee Somnath, Boilevin Jérémy, Irobalieva Rossitza N., Darbre Tamis, Scott Nichollas E., Reymond Jean-Louis, Kossiakoff Anthony A., et al.
, Nat Chem Biol, 2023 Jan 05, (2023)
Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1.,
Chen, Qiuyan, Plasencia Manolo, Li Zhuang, Mukherjee Somnath, Patra Dhabaleswar, Chen Chun-Liang, Klose Thomas, Yao Xin-Qiu, Kossiakoff Anthony A., Chang Leifu, et al.
, Nature, 2021 Jul 14, (2021)
Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins.,
Mukherjee, Somnath, Erramilli Satchal K., Ammirati Mark, Alvarez Frances J. D., Fennell Kimberly F., Purdy Michael D., Skrobek Blazej M., Radziwon Katarzyna, Coukos John, Kang Yanyong, et al.
, Nat Commun, March 27 2020, Volume 11, Issue 1, p.1598, (2020)
Synthetic Antibodies Detect Distinct Cellular States of Chromosome Passenger Complex Proteins.,
Ura, Marcin, Mukherjee Somnath, Marcon Edyta, Koestler Stefan A., and Kossiakoff Anthony A.
, J Mol Biol, 2022 Jun 30, Volume 434, Issue 12, p.167602, (2022)
T
Targeted rescue of cancer-associated IDH1 mutant activity using an engineered synthetic antibody.,
Rizk, Shahir S., Mukherjee Somnath, Koide Akiko, Koide Shohei, and Kossiakoff Anthony A.
, Sci Rep, 2017 04 03, Volume 7, Issue 1, p.556, (2017)
Publications
- Characterization of synthetic antigen binding fragments targeting Toc75 for the isolation of TOC in A. thaliana and P. sativum.
- Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
- Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes.
- Engineering of a synthetic antibody fragment for structural and functional studies of K+ channels.
- Isoform- and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder.
- Quaternary structure independent folding of voltage-gated ion channel pore domain subunits.
- Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
- Structure of an AMPK complex in an inactive, ATP-bound state.
- Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver.
- Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase.
- Structures of ABCB4 provide insight into phosphatidylcholine translocation.
- Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.
- Synthetic Antibodies Detect Distinct Cellular States of Chromosome Passenger Complex Proteins.
- Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers.