Quaternary structure independent folding of voltage-gated ion channel pore domain subunits.
Posted on April 3, 2023
Title | Quaternary structure independent folding of voltage-gated ion channel pore domain subunits. |
Publication Type | Journal Article |
Authors | Arrigoni, Cristina, Lolicato Marco, Shaya David, Rohaim Ahmed, Findeisen Felix, Fong Lam-Kiu, Colleran Claire M., Dominik Pawel, Kim Sangwoo S., Schuermann Jonathan P., DeGrado William F., Grabe Michael, Kossiakoff Anthony A., and Minor Daniel L. |
PubMed ID | 35655098 |
PubMed Central ID | PMC9809158 |
Grant List | R01 HL080050 / HL / NHLBI NIH HHS / United States R21 GM100224 / GM / NIGMS NIH HHS / United States R01 GM117372 / GM / NIGMS NIH HHS / United States P30 GM124165 / GM / NIGMS NIH HHS / United States R35 GM122603 / GM / NIGMS NIH HHS / United States R01 GM137109 / GM / NIGMS NIH HHS / United States R01 DC007664 / DC / NIDCD NIH HHS / United States |
Publications
- Characterization of synthetic antigen binding fragments targeting Toc75 for the isolation of TOC in A. thaliana and P. sativum.
- Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
- Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes.
- Engineering of a synthetic antibody fragment for structural and functional studies of K+ channels.
- Isoform- and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder.
- Quaternary structure independent folding of voltage-gated ion channel pore domain subunits.
- Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
- Structure of an AMPK complex in an inactive, ATP-bound state.
- Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver.
- Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase.
- Structures of ABCB4 provide insight into phosphatidylcholine translocation.
- Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.
- Synthetic Antibodies Detect Distinct Cellular States of Chromosome Passenger Complex Proteins.
- Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers.
RAN Publications
Latest publications
-
Conformation-specific Synthetic Antibodies Discriminate Multiple Functional States of the Ion Channel CorA. (published on 2023 Jul 01)
-
Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. (published on 2023 Mar 16)