Publications
T
Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers.,
Lim, Shion A., Zhou Jie, Martinko Alexander J., Wang Yung-Hua, Filippova Ekaterina V., Steri Veronica, Wang Donghui, Remesh Soumya G., Liu Jia, Hann Byron, et al.
, J Clin Invest, 2022 Feb 15, Volume 132, Issue 4, (2022)
Targeted rescue of cancer-associated IDH1 mutant activity using an engineered synthetic antibody.,
Rizk, Shahir S., Mukherjee Somnath, Koide Akiko, Koide Shohei, and Kossiakoff Anthony A.
, Sci Rep, 2017 04 03, Volume 7, Issue 1, p.556, (2017)
S
Synthetic Antibodies Detect Distinct Cellular States of Chromosome Passenger Complex Proteins.,
Ura, Marcin, Mukherjee Somnath, Marcon Edyta, Koestler Stefan A., and Kossiakoff Anthony A.
, J Mol Biol, 2022 Jun 30, Volume 434, Issue 12, p.167602, (2022)
Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins.,
Mukherjee, Somnath, Erramilli Satchal K., Ammirati Mark, Alvarez Frances J. D., Fennell Kimberly F., Purdy Michael D., Skrobek Blazej M., Radziwon Katarzyna, Coukos John, Kang Yanyong, et al.
, Nat Commun, March 27 2020, Volume 11, Issue 1, p.1598, (2020)
Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1.,
Chen, Qiuyan, Plasencia Manolo, Li Zhuang, Mukherjee Somnath, Patra Dhabaleswar, Chen Chun-Liang, Klose Thomas, Yao Xin-Qiu, Kossiakoff Anthony A., Chang Leifu, et al.
, Nature, 2021 Jul 14, (2021)
Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.,
Yen, Yu-Chen, Schafer Christopher T., Gustavsson Martin, Eberle Stefanie A., Dominik Pawel K., Deneka Dawid, Zhang Penglie, Schall Thomas J., Kossiakoff Anthony A., Tesmer John J. G., et al.
, Sci Adv, 2022 Jul 15, Volume 8, Issue 28, p.eabn8063, (2022)
Structures of ABCB4 provide insight into phosphatidylcholine translocation.,
Nosol, Kamil, Bang-Sørensen Rose, Irobalieva Rossitza N., Erramilli Satchal K., Stieger Bruno, Kossiakoff Anthony A., and Locher Kaspar P.
, Proc Natl Acad Sci U S A, 2021 Aug 17, Volume 118, Issue 33, (2021)
Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase.,
Bloch, Joël S., John Alan, Mao Runyu, Mukherjee Somnath, Boilevin Jérémy, Irobalieva Rossitza N., Darbre Tamis, Scott Nichollas E., Reymond Jean-Louis, Kossiakoff Anthony A., et al.
, Nat Chem Biol, 2023 Jan 05, (2023)
The structure of the C-terminal domain of the nucleoprotein from the Bundibugyo strain of the Ebola virus in complex with a pan-specific synthetic Fab.,
Radwańska, Malwina J., Jaskółowski Mateusz, Davydova Elena, Derewenda Urszula, Miyake Tsuyoshi, Engel Daniel A., Kossiakoff Anthony A., and Derewenda Zygmunt S.
, Acta Crystallogr D Struct Biol, 2018 07 01, Volume 74, Issue Pt 7, p.681-689, (2018)
Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver.,
Liu, Hongtao, Irobalieva Rossitza N., Bang-Sørensen Rose, Nosol Kamil, Mukherjee Somnath, Agrawal Parth, Stieger Bruno, Kossiakoff Anthony A., and Locher Kaspar P.
, Cell Res, 2022 Aug, Volume 32, Issue 8, p.773-776, (2022)
Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling.,
Tsutsumi, Naotaka, Mukherjee Somnath, Waghray Deepa, Janda Claudia Y., Jude Kevin M., Miao Yi, Burg John S., Aduri Nanda Gowtham, Kossiakoff Anthony A., Gati Cornelius, et al.
, Elife, August 7 2020, Volume 9, (2020)
Structure of an AMPK complex in an inactive, ATP-bound state.,
Yan, Yan, Mukherjee Somnath, Harikumar Kaleeckal G., Strutzenberg Timothy S., X Zhou Edward, Suino-Powell Kelly, Xu Ting-Hai, Sheldon Ryan D., Lamp Jared, Brunzelle Joseph S., et al.
, Science, 2021 Jul 23, Volume 373, Issue 6553, p.413-419, (2021)
Structure and mechanism of the ER-based glucosyltransferase ALG6.,
Bloch, Joël S., Pesciullesi Giorgio, Boilevin Jérémy, Nosol Kamil, Irobalieva Rossitza N., Darbre Tamis, Aebi Markus, Kossiakoff Anthony A., Reymond Jean-Louis, and Locher Kaspar P.
, Nature, 03/2020, Volume 579, Issue 7799, p.443-447, (2020)
Structure and drug resistance of the Plasmodium falciparum transporter PfCRT.,
Kim, Jonathan, Tan Yong Zi, Wicht Kathryn J., Erramilli Satchal K., Dhingra Satish K., Okombo John, Vendome Jeremie, Hagenah Laura M., Giacometti Sabrina I., Warren Audrey L., et al.
, Nature, 2019 12, Volume 576, Issue 7786, p.315-320, (2019)
Structural basis of omega-3 fatty acid transport across the blood-brain barrier.,
Cater, Rosemary J., Chua Geok Lin, Erramilli Satchal K., Keener James E., Choy Brendon C., Tokarz Piotr, Chin Cheen Fei, Q Y Quek Debra, Kloss Brian, Pepe Joseph G., et al.
, Nature, 2021 Jun 16, (2021)
Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.,
Kern, David M., Bleier Julia, Mukherjee Somnath, Hill Jennifer M., Kossiakoff Anthony A., Isacoff Ehud Y., and Brohawn Stephen G.
, Nat Struct Mol Biol, 2023 Mar 16, (2023)
Structural basis for activation of voltage sensor domains in an ion channel TPC1.,
Kintzer, Alexander F., Green Evan M., Dominik Pawel K., Bridges Michael, Armache Jean-Paul, Deneka Dawid, Kim Sangwoo S., Hubbell Wayne, Kossiakoff Anthony A., Cheng Yifan, et al.
, Proc Natl Acad Sci U S A, 2018 09 25, Volume 115, Issue 39, p.E9095-E9104, (2018)
Structural basis for activation of SAGA histone acetyltransferase Gcn5 by partner subunit Ada2.,
Sun, Jian, Paduch Marcin, Kim Sang-Ah, Kramer Ryan M., Barrios Adam F., Lu Vincent, Luke Judy, Usatyuk Svitlana, Kossiakoff Anthony A., and Tan Song
, Proc Natl Acad Sci U S A, 2018 10 02, Volume 115, Issue 40, p.10010-10015, (2018)
Specific Recognition of a Single-Stranded RNA Sequence by a Synthetic Antibody Fragment.,
Shao, Yaming, Huang Hao, Qin Daoming, Li Nan-Sheng, Koide Akiko, Staley Jonathan P., Koide Shohei, Kossiakoff Anthony A., and Piccirilli Joseph A.
, J Mol Biol, 2016 10 09, Volume 428, Issue 20, p.4100-4114, (2016)
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Recognition of an α-helical hairpin in P22 large terminase by a synthetic antibody fragment.,
Lokareddy, Ravi K., Ko Ying Hui, Hong Nathaniel, Doll Steven G., Paduch Marcin, Niederweis Michael, Kossiakoff Anthony A., and Cingolani Gino
, Acta Crystallogr D Struct Biol, September 1 2020, Volume 76, Issue Pt 9, p.876-888, (2020)
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Quaternary structure independent folding of voltage-gated ion channel pore domain subunits.,
Arrigoni, Cristina, Lolicato Marco, Shaya David, Rohaim Ahmed, Findeisen Felix, Fong Lam-Kiu, Colleran Claire M., Dominik Pawel, Kim Sangwoo S., Schuermann Jonathan P., et al.
, Nat Struct Mol Biol, 2022 Jun, Volume 29, Issue 6, p.537-548, (2022)
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Prolactin Receptor-Mediated Internalization of Imaging Agents Detects Epithelial Ovarian Cancer with Enhanced Sensitivity and Specificity.,
Sundaram, Karthik M., Zhang Yilin, Mitra Anirban K., Kouadio Jean-Louis K., Gwin Katja, Kossiakoff Anthony A., Roman Brian B., Lengyel Ernst, and Piccirilli Joseph A.
, Cancer Res, 2017 Apr 01, Volume 77, Issue 7, p.1684-1696, (2017)
The Preserved HTH-Docking Cleft of HIV-1 Integrase Is Functionally Critical.,
Galilee, Meytal, Britan-Rosich Elena, Griner Sarah L., Uysal Serdar, Baumgärtel Viola, Lamb Don C., Kossiakoff Anthony A., Kotler Moshe, Stroud Robert M., Marx Ailie, et al.
, Structure, 2016 11 01, Volume 24, Issue 11, p.1936-1946, (2016)
A polar ring endows improved specificity to an antibody fragment.,
Schaefer, Zachary P., Bailey Lucas J., and Kossiakoff Anthony A.
, Protein Sci, 2016 07, Volume 25, Issue 7, p.1290-8, (2016)
O
Optimizing Production of Antigens and Fabs in the Context of Generating Recombinant Antibodies to Human Proteins.,
Zhong, Nan, Loppnau Peter, Seitova Alma, Ravichandran Mani, Fenner Maria, Jain Harshika, Bhattacharya Anandi, Hutchinson Ashley, Paduch Marcin, Lu Vincent, et al.
, PLoS One, 2015, Volume 10, Issue 10, p.e0139695, (2015)
Pages
Publications
- Characterization of synthetic antigen binding fragments targeting Toc75 for the isolation of TOC in A. thaliana and P. sativum.
- Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
- Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes.
- Engineering of a synthetic antibody fragment for structural and functional studies of K+ channels.
- Isoform- and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder.
- Quaternary structure independent folding of voltage-gated ion channel pore domain subunits.
- Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
- Structure of an AMPK complex in an inactive, ATP-bound state.
- Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver.
- Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase.
- Structures of ABCB4 provide insight into phosphatidylcholine translocation.
- Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.
- Synthetic Antibodies Detect Distinct Cellular States of Chromosome Passenger Complex Proteins.
- Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers.