Publications
2017
Targeted rescue of cancer-associated IDH1 mutant activity using an engineered synthetic antibody.,
Rizk, Shahir S., Mukherjee Somnath, Koide Akiko, Koide Shohei, and Kossiakoff Anthony A.
, Sci Rep, 2017 04 03, Volume 7, Issue 1, p.556, (2017)
2018
Structural basis for activation of SAGA histone acetyltransferase Gcn5 by partner subunit Ada2.,
Sun, Jian, Paduch Marcin, Kim Sang-Ah, Kramer Ryan M., Barrios Adam F., Lu Vincent, Luke Judy, Usatyuk Svitlana, Kossiakoff Anthony A., and Tan Song
, Proc Natl Acad Sci U S A, 2018 10 02, Volume 115, Issue 40, p.10010-10015, (2018)
Publications
- Characterization of synthetic antigen binding fragments targeting Toc75 for the isolation of TOC in A. thaliana and P. sativum.
- Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
- Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes.
- Engineering of a synthetic antibody fragment for structural and functional studies of K+ channels.
- Isoform- and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder.
- Quaternary structure independent folding of voltage-gated ion channel pore domain subunits.
- Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
- Structure of an AMPK complex in an inactive, ATP-bound state.
- Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver.
- Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase.
- Structures of ABCB4 provide insight into phosphatidylcholine translocation.
- Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.
- Synthetic Antibodies Detect Distinct Cellular States of Chromosome Passenger Complex Proteins.
- Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers.