Publications
2022
Engineering of a synthetic antibody fragment for structural and functional studies of K+ channels.,
Rohaim, Ahmed, Slezak Tomasz, Koh Young Hoon, Blachowicz Lydia, Kossiakoff Anthony A., and Roux Benoît
, J Gen Physiol, 2022 Apr 04, Volume 154, Issue 4, (2022)
2019
Development of "Plug and Play" Fiducial Marks for Structural Studies of GPCR Signaling Complexes by Single-Particle Cryo-EM.,
Dutka, Przemyslaw, Mukherjee Somnath, Gao Xiang, Kang Yanyong, de Waal Parker W., Wang Lei, Zhuang Youwen, Melcher Karsten, Zhang Cheng, H Xu Eric, et al.
, Structure, 2019 12 03, Volume 27, Issue 12, p.1862-1874.e7, (2019)
Rapid Discovery and Characterization of Synthetic Neutralizing Antibodies against Anthrax Edema Toxin.,
Farcasanu, Mara, Wang Andrew G., Uchański Tomasz, Bailey Lucas J., Yue Jiping, Chen Zhaochun, Wu Xiaoyang, Kossiakoff Anthony, and Tang Wei-Jen
, Biochemistry, 2019 07 09, Volume 58, Issue 27, p.2996-3004, (2019)
2017
Creation of Phosphotyrosine Superbinders by Directed Evolution of an SH2 Domain.,
Huang, Haiming, Kaneko Tomonori, Sidhu Sachdev S., and Li Shawn S. C.
, Methods Mol Biol, 2017, Volume 1555, p.225-254, (2017)
2015
Architecture of the fungal nuclear pore inner ring complex.,
Stuwe, Tobias, Bley Christopher J., Thierbach Karsten, Petrovic Stefan, Schilbach Sandra, Mayo Daniel J., Perriches Thibaud, Rundlet Emily J., Jeon Young E., Collins Leslie N., et al.
, Science, 2015 Oct 02, Volume 350, Issue 6256, p.56-64, (2015)
An improved single-chain Fab platform for efficient display and recombinant expression.,
Koerber, James T., Hornsby Michael J., and Wells James A.
, J Mol Biol, 2015 Jan 30, Volume 427, Issue 2, p.576-86, (2015)
Selection of recombinant anti-SH3 domain antibodies by high-throughput phage display.,
Huang, Haiming, Economopoulos Nicolas O., Liu Bernard A., Uetrecht Andrea, Gu Jun, Jarvik Nick, Nadeem Vincent, Pawson Tony, Moffat Jason, Miersch Shane, et al.
, Protein Sci, 2015 Nov, Volume 24, Issue 11, p.1890-900, (2015)
Publications
- Characterization of synthetic antigen binding fragments targeting Toc75 for the isolation of TOC in A. thaliana and P. sativum.
- Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
- Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes.
- Engineering of a synthetic antibody fragment for structural and functional studies of K+ channels.
- Isoform- and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder.
- Quaternary structure independent folding of voltage-gated ion channel pore domain subunits.
- Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
- Structure of an AMPK complex in an inactive, ATP-bound state.
- Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver.
- Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase.
- Structures of ABCB4 provide insight into phosphatidylcholine translocation.
- Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.
- Synthetic Antibodies Detect Distinct Cellular States of Chromosome Passenger Complex Proteins.
- Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers.