Publications

Found 56 results
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2020
An engineered ultra-high affinity Fab-Protein G pair enables a modular antibody platform with multifunctional capability., Slezak, Tomasz, Bailey Lucas J., Jaskolowski Mateusz, Nahotko Dominik A., Filippova Ekaterina V., Davydova Elena K., and Kossiakoff Anthony A. , Protein Sci, 2020 01, Volume 29, Issue 1, p.141-156, (2020)
Recognition of an α-helical hairpin in P22 large terminase by a synthetic antibody fragment., Lokareddy, Ravi K., Ko Ying Hui, Hong Nathaniel, Doll Steven G., Paduch Marcin, Niederweis Michael, Kossiakoff Anthony A., and Cingolani Gino , Acta Crystallogr D Struct Biol, September 1 2020, Volume 76, Issue Pt 9, p.876-888, (2020)
Structure and mechanism of the ER-based glucosyltransferase ALG6., Bloch, Joël S., Pesciullesi Giorgio, Boilevin Jérémy, Nosol Kamil, Irobalieva Rossitza N., Darbre Tamis, Aebi Markus, Kossiakoff Anthony A., Reymond Jean-Louis, and Locher Kaspar P. , Nature, 03/2020, Volume 579, Issue 7799, p.443-447, (2020)
Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling., Tsutsumi, Naotaka, Mukherjee Somnath, Waghray Deepa, Janda Claudia Y., Jude Kevin M., Miao Yi, Burg John S., Aduri Nanda Gowtham, Kossiakoff Anthony A., Gati Cornelius, et al. , Elife, August 7 2020, Volume 9, (2020)
Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins., Mukherjee, Somnath, Erramilli Satchal K., Ammirati Mark, Alvarez Frances J. D., Fennell Kimberly F., Purdy Michael D., Skrobek Blazej M., Radziwon Katarzyna, Coukos John, Kang Yanyong, et al. , Nat Commun, March 27 2020, Volume 11, Issue 1, p.1598, (2020)
2018
Cryo-EM structure of human rhodopsin bound to an inhibitory G protein., Kang, Yanyong, Kuybeda Oleg, de Waal Parker W., Mukherjee Somnath, Van Eps Ned, Dutka Przemyslaw, X Zhou Edward, Bartesaghi Alberto, Erramilli Satchal, Morizumi Takefumi, et al. , Nature, 2018 06, Volume 558, Issue 7711, p.553-558, (2018)
Engineered synthetic antibodies as probes to quantify the energetic contributions of ligand binding to conformational changes in proteins., Mukherjee, Somnath, Griffin Dionne H., Horn James R., Rizk Shahir S., Nocula-Lugowska Malgorzata, Malmqvist Magnus, Kim Sangwoo S., and Kossiakoff Anthony A. , J Biol Chem, 2018 02 23, Volume 293, Issue 8, p.2815-2828, (2018)
Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme., Zhang, Zhening, Liang Wenguang G., Bailey Lucas J., Tan Yong Zi, Wei Hui, Wang Andrew, Farcasanu Mara, Woods Virgil A., McCord Lauren A., Lee David, et al. , Elife, 03/2018, Volume 7, (2018)
Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies., Pollock, Samuel B., Hu Amy, Mou Yun, Martinko Alexander J., Julien Olivier, Hornsby Michael, Ploder Lynda, Adams Jarrett J., Geng Huimin, Müschen Markus, et al. , Proc Natl Acad Sci U S A, 2018 03 13, Volume 115, Issue 11, p.2836-2841, (2018)
Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination., Bailey, Lucas J., Sheehy Kimberly M., Dominik Pawel K., Liang Wenguang G., Rui Huan, Clark Michael, Jaskolowski Mateusz, Kim Yejoon, Deneka Dawid, Tang Wei-Jen, et al. , J Mol Biol, 2018 02 02, Volume 430, Issue 3, p.337-347, (2018)
Structural basis for activation of SAGA histone acetyltransferase Gcn5 by partner subunit Ada2., Sun, Jian, Paduch Marcin, Kim Sang-Ah, Kramer Ryan M., Barrios Adam F., Lu Vincent, Luke Judy, Usatyuk Svitlana, Kossiakoff Anthony A., and Tan Song , Proc Natl Acad Sci U S A, 2018 10 02, Volume 115, Issue 40, p.10010-10015, (2018)
Structural basis for activation of voltage sensor domains in an ion channel TPC1., Kintzer, Alexander F., Green Evan M., Dominik Pawel K., Bridges Michael, Armache Jean-Paul, Deneka Dawid, Kim Sangwoo S., Hubbell Wayne, Kossiakoff Anthony A., Cheng Yifan, et al. , Proc Natl Acad Sci U S A, 2018 09 25, Volume 115, Issue 39, p.E9095-E9104, (2018)
The structure of the C-terminal domain of the nucleoprotein from the Bundibugyo strain of the Ebola virus in complex with a pan-specific synthetic Fab., Radwańska, Malwina J., Jaskółowski Mateusz, Davydova Elena, Derewenda Urszula, Miyake Tsuyoshi, Engel Daniel A., Kossiakoff Anthony A., and Derewenda Zygmunt S. , Acta Crystallogr D Struct Biol, 2018 07 01, Volume 74, Issue Pt 7, p.681-689, (2018)
2017
Creation of Phosphotyrosine Superbinders by Directed Evolution of an SH2 Domain., Huang, Haiming, Kaneko Tomonori, Sidhu Sachdev S., and Li Shawn S. C. , Methods Mol Biol, 2017, Volume 1555, p.225-254, (2017)
Fc Engineering for Developing Therapeutic Bispecific Antibodies and Novel Scaffolds., Liu, Hongyan, Saxena Abhishek, Sidhu Sachdev S., and Wu Donghui , Front Immunol, 2017, Volume 8, p.38, (2017)
Generating Conformation and Complex-Specific Synthetic Antibodies., Paduch, Marcin, and Kossiakoff Anthony A. , Methods Mol Biol, 2017, Volume 1575, p.93-119, (2017)
A Highly Diverse and Functional Naïve Ubiquitin Variant Library for Generation of Intracellular Affinity Reagents., Leung, Isabel, Jarvik Nick, and Sidhu Sachdev S. , J Mol Biol, 2017 01 06, Volume 429, Issue 1, p.115-127, (2017)
Prolactin Receptor-Mediated Internalization of Imaging Agents Detects Epithelial Ovarian Cancer with Enhanced Sensitivity and Specificity., Sundaram, Karthik M., Zhang Yilin, Mitra Anirban K., Kouadio Jean-Louis K., Gwin Katja, Kossiakoff Anthony A., Roman Brian B., Lengyel Ernst, and Piccirilli Joseph A. , Cancer Res, 2017 Apr 01, Volume 77, Issue 7, p.1684-1696, (2017)
Redox-based reagents for chemoselective methionine bioconjugation., Lin, Shixian, Yang Xiaoyu, Jia Shang, Weeks Amy M., Hornsby Michael, Lee Peter S., Nichiporuk Rita V., Iavarone Anthony T., Wells James A., F Toste Dean, et al. , Science, 2017 02 10, Volume 355, Issue 6325, p.597-602, (2017)
Targeted rescue of cancer-associated IDH1 mutant activity using an engineered synthetic antibody., Rizk, Shahir S., Mukherjee Somnath, Koide Akiko, Koide Shohei, and Kossiakoff Anthony A. , Sci Rep, 2017 04 03, Volume 7, Issue 1, p.556, (2017)

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