Welcome to the Recombinant Antibody Network

The Recombinant Antibody Network is a consortium of highly integrated technology centers at UCSF, the University of Chicago, and the University of Toronto, unified under a common goal to generate therapeutic grade recombinant antibodies at a proteome wide scale for biology and biomedicine.

Given that over half the human proteome is not annotated and that functional antibodies are not reliably available, a complete set of validated antibodies would greatly advance all areas of biology, including cancer therapy and infectious disease control. To undertake these challenges, RAN is systematically and comprehensively profiling families of protein targets using novel, modern high-throughput in vitro technology.

Latest Publications

Synthetic antibodies targeting EphA2 induce diverse signaling-competent clusters with differential activation

Adams J J; Bruce H A; Subramania S; Ploder L; Garcia J; Pot I; Blazer L L; Singer A U; Sidhu S S

Synthetic antibodies targeting EphA2 induce diverse signaling-competent clusters with differential activation Journal Article

In: Protein Sci, vol. 34, no. 6, pp. e70145, 2025, ISSN: 1469-896X.

Abstract | Links

Molecular characterization of a synthetic neutralizing antibody targeting p67 of Theileria parva

Miersch S; Singer A U; Chen C; Fellouse F; Gopalsamy A; Costa L S E; Lacasta A; Chege H; Chege N; Nene V; Sidhu S S

Molecular characterization of a synthetic neutralizing antibody targeting p67 of Theileria parva Journal Article

In: Protein Sci, vol. 34, no. 6, pp. e70153, 2025, ISSN: 1469-896X.

Abstract | Links

Locking CBL TKBD in its native conformation presents a novel therapeutic opportunity in mutant CBL-dependent leukemia

Ahmed S F; Anand J; Zhang W; Buetow L; Rishi L; Mitchell L; Bohlen J; Lilla S; Sibbet G J; Nixon C; Patel A; Majorek K A; Zanivan S; Bustamante J C; Sidhu S S; Blyth K; Huang D T

Locking CBL TKBD in its native conformation presents a novel therapeutic opportunity in mutant CBL-dependent leukemia Journal Article

In: Mol Ther, 2025, ISSN: 1525-0024.

Abstract | Links

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