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234 entries « 2 of 12 »

Kordon, Szymon P; Cechova, Kristina; Bandekar, Sumit J; Leon, Katherine; Dutka, Przemysław; Siffer, Gracie; Kossiakoff, Anthony A; Vafabakhsh, Reza; Araç, Demet

Conformational coupling between extracellular and transmembrane domains modulates holo-adhesion GPCR function Journal Article

In: Nat Commun, vol. 15, no. 1, pp. 10545, 2024, ISSN: 2041-1723.

Abstract | Links | BibTeX

Conformational coupling between extracellular and transmembrane domains modulates holo-adhesion GPCR function

Teter, Olivia M; McQuade, Amanda; Hagan, Venus; Liang, Weiwei; Dräger, Nina M; Sattler, Sydney M; Holmes, Brandon B; Castillo, Vincent Cele; Papakis, Vasileios; Leng, Kun; Boggess, Steven; Nowakowski, Tomasz J; Wells, James; Kampmann, Martin

CRISPRi-based screen of Autism Spectrum Disorder risk genes in microglia uncovers roles of in microglia endocytosis and synaptic pruning Journal Article

In: bioRxiv, 2024, ISSN: 2692-8205.

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CRISPRi-based screen of Autism Spectrum Disorder risk genes in microglia uncovers roles of  in microglia endocytosis and synaptic pruning

Martyn, Gregory D; Kalagiri, Rajasree; Veggiani, Gianluca; Stanfield, Robyn L; Choudhuri, Indrani; Sala, Margaux; Meisenhelder, Jill; Chen, Chao; Biswas, Avik; Levy, Ronald M; Lyumkis, Dmitry; Wilson, Ian A; Hunter, Tony; Sidhu, Sachdev S

Using phage display for rational engineering of a higher affinity humanized 3' phosphohistidine-specific antibody Journal Article

In: bioRxiv, 2024, ISSN: 2692-8205.

Abstract | Links | BibTeX

Using phage display for rational engineering of a higher affinity humanized 3' phosphohistidine-specific antibody

Rathnayake, Sewwandi S; Erramilli, Satchal K; Kossiakoff, Anthony A; Vecchio, Alex J

Cryo-EM structures of Clostridium perfringens enterotoxin bound to its human receptor, claudin-4 Journal Article

In: Structure, vol. 32, no. 11, pp. 1936–1951.e5, 2024, ISSN: 1878-4186.

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Cryo-EM structures of Clostridium perfringens enterotoxin bound to its human receptor, claudin-4

Ross, Philipp; Hilton, Hugo G; Lodwick, Jane; Slezak, Tomasz; Guethlein, Lisbeth A; McMurtrey, Curtis P; Han, Alex S; Nielsen, Morten; Yong, Daniel; Dulberger, Charles L; Nolan, Kristof T; Roy, Sobhan; Castro, Caitlin D; Hildebrand, William H; Zhao, Minglei; Kossiakoff, Anthony; Parham, Peter; Adams, Erin J

Molecular characterization of the archaic HLA-B*73:01 allele reveals presentation of a unique peptidome and skewed engagement by KIR2DL2 Journal Article

In: bioRxiv, 2024, ISSN: 2692-8205.

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Molecular characterization of the archaic HLA-B*73:01 allele reveals presentation of a unique peptidome and skewed engagement by KIR2DL2

Ogbu, Chinemerem P; Mandriota, Alexandria M; Liu, Xiangdong; de Las Alas, Mason; Kapoor, Srajan; Choudhury, Jagrity; Kossiakoff, Anthony A; Duffey, Michael E; Vecchio, Alex J

Biophysical Basis of Paracellular Barrier Modulation by a Pan-Claudin-Binding Molecule Journal Article

In: bioRxiv, 2024, ISSN: 2692-8205.

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Biophysical Basis of Paracellular Barrier Modulation by a Pan-Claudin-Binding Molecule

Delaveris, Corleone S; Kong, Sophie; Glasgow, Jeff; Loudermilk, Rita P; Kirkemo, Lisa L; Zhao, Fangzhu; Salangsang, Fernando; Phojanakong, Paul; Serrano, Juan Antonio Camara; Steri, Veronica; Wells, James A

Chemoproteomics reveals immunogenic and tumor-associated cell surface substrates of ectokinase CK2α Journal Article

In: Cell Chem Biol, vol. 31, no. 9, pp. 1729–1739.e9, 2024, ISSN: 2451-9448.

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Chemoproteomics reveals immunogenic and tumor-associated cell surface substrates of ectokinase CK2α

Samassekou, Kadidia; Garland-Kuntz, Elisabeth E; Ohri, Vaani; Fisher, Isaac J; Erramilli, Satchal K; Muralidharan, Kaushik; Bogdan, Livia M; Gick, Abigail M; Kossiakoff, Anthony A; Lyon, Angeline M

Cryo-EM Structure of Phospholipase Cε Defines N-terminal Domains and their Roles in Activity Journal Article

In: bioRxiv, 2024, ISSN: 2692-8205.

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Cryo-EM Structure of Phospholipase Cε Defines N-terminal Domains and their Roles in Activity

Liu, Yaqi; Brown, Chelsea M; Borges, Nuno; Nobre, Rodrigo N; Erramilli, Satchal; Dufrisne, Meagan Belcher; Kloss, Brian; Giacometti, Sabrina; Esteves, Ana M; Timoteo, Cristina G; Tokarz, Piotr; Cater, Rosemary; Morita, Yasu S; Kossiakoff, Anthony A; Santos, Helena; Stansfeld, Phillip J; Nygaard, Rie; Mancia, Filippo

Mechanistic studies of mycobacterial glycolipid biosynthesis by the mannosyltransferase PimE Journal Article

In: bioRxiv, 2024, ISSN: 2692-8205.

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Mechanistic studies of mycobacterial glycolipid biosynthesis by the mannosyltransferase PimE

Liu, Yaqi; Brown, Chelsea M; Erramilli, Satchal; Su, Yi-Chia; Tseng, Po-Sen; Wang, Yu-Jen; Duong, Nam Ha; Tokarz, Piotr; Kloss, Brian; Han, Cheng-Ruei; Chen, Hung-Yu; Rodrigues, Jose; Archer, Margarida; Lowary, Todd L; Kossiakoff, Anthony A; Stansfeld, Phillip J; Nygaard, Rie; Mancia, Filippo

Structural insights into terminal arabinosylation biosynthesis of the mycobacterial cell wall arabinan Journal Article

In: bioRxiv, 2024, ISSN: 2692-8205.

Abstract | Links | BibTeX

Structural insights into terminal arabinosylation biosynthesis of the mycobacterial cell wall arabinan

Slezak, Tomasz; O'Leary, Kelly M; Li, Jinyang; Rohaim, Ahmed; Davydova, Elena K; Kossiakoff, Anthony A

Engineered Protein-G variants for plug-and-play applications Journal Article

In: bioRxiv, 2024, ISSN: 2692-8205.

Abstract | Links | BibTeX

Engineered Protein-G variants for plug-and-play applications

McHenry, Matthew W; Shi, Peiwen; Camara, Christina M; Cohen, Daniel T; Rettenmaier, T Justin; Adhikary, Utsarga; Gygi, Micah A; Yang, Ka; Gygi, Steven P; Wales, Thomas E; Engen, John R; Wells, James A; Walensky, Loren D

Covalent inhibition of pro-apoptotic BAX Journal Article

In: Nat Chem Biol, vol. 20, no. 8, pp. 1022–1032, 2024, ISSN: 1552-4469.

Abstract | Links | BibTeX

Covalent inhibition of pro-apoptotic BAX

Knejski, Paweł P; Erramilli, Satchal K; Kossiakoff, Anthony A

Chaperone-assisted cryo-EM structure of PhuR reveals molecular basis for heme binding Journal Article

In: bioRxiv, 2024, ISSN: 2692-8205.

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Chaperone-assisted cryo-EM structure of  PhuR reveals molecular basis for heme binding

Bruce, Heather A.; Singer, Alexander U.; Blazer, Levi L.; Luu, Khanh; Ploder, Lynda; Pavlenco, Alevtina; Kurinov, Igor; Adams, Jarrett J.; Sidhu, Sachdev S.

Antigen‐binding fragments with improved crystal lattice packing and enhanced conformational flexibility at the elbow region as crystallization chaperones Journal Article

In: Protein Science, vol. 33, no. 7, 2024, ISSN: 1469-896X.

Abstract | Links | BibTeX

Antigen‐binding fragments with improved crystal lattice packing and enhanced conformational flexibility at the elbow region as crystallization chaperones

Zhou, Xin; Kong, Sophie; Maker, Allison; Remesh, Soumya G; Leung, Kevin K; Verba, Kliment A; Wells, James A

Antibody discovery identifies regulatory mechanisms of protein arginine deiminase 4 Journal Article

In: Nat Chem Biol, vol. 20, no. 6, pp. 742–750, 2024, ISSN: 1552-4469.

Abstract | Links | BibTeX

Antibody discovery identifies regulatory mechanisms of protein arginine deiminase 4

Lan, Tong; Slezak, Tomasz; Pu, Jinyue; Zinkus-Boltz, Julia; Adhikari, Sarbani; Pekow, Joel R; Taneja, Vibha; Zuniga, Joaquin; Gómez-García, Itzel A; Regino-Zamarripa, Nora; Ahmed, Mushtaq; Khader, Shabaana A; Rubin, David T; Kossiakoff, Anthony A; Dickinson, Bryan C

Development of Luminescent Biosensors for Calprotectin Journal Article

In: ACS Chem Biol, vol. 19, no. 6, pp. 1250–1259, 2024, ISSN: 1554-8937.

Abstract | Links | BibTeX

Development of Luminescent Biosensors for Calprotectin

Erramilli, Satchal K; Dominik, Pawel K; Ogbu, Chinemerem P; Kossiakoff, Anthony A; Vecchio, Alex J

Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment Journal Article

In: Commun Biol, vol. 7, no. 1, pp. 733, 2024, ISSN: 2399-3642.

Abstract | Links | BibTeX

Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment

Lodwick, Jane E; Shen, Rong; Erramilli, Satchal; Xie, Yuan; Roganowicz, Karolina; Kossiakoff, Anthony A; Zhao, Minglei

Structural Insights into the Roles of PARP4 and NAD in the Human Vault Cage Journal Article

In: bioRxiv, 2024, ISSN: 2692-8205.

Abstract | Links | BibTeX

Structural Insights into the Roles of PARP4 and NAD  in the Human Vault Cage

Cater, Rosemary J; Mukherjee, Dibyanti; Gil-Iturbe, Eva; Erramilli, Satchal K; Chen, Ting; Koo, Katie; Santander, Nicolás; Reckers, Andrew; Kloss, Brian; Gawda, Tomasz; Choy, Brendon C; Zhang, Zhening; Katewa, Aditya; Larpthaveesarp, Amara; Huang, Eric J; Mooney, Scott W J; Clarke, Oliver B; Yee, Sook Wah; Giacomini, Kathleen M; Kossiakoff, Anthony A; Quick, Matthias; Arnold, Thomas; Mancia, Filippo

Structural and molecular basis of choline uptake into the brain by FLVCR2 Journal Article

In: Nature, vol. 629, no. 8012, pp. 704–709, 2024, ISSN: 1476-4687.

Abstract | Links | BibTeX

Structural and molecular basis of choline uptake into the brain by FLVCR2

Zhou, Jie; Le, Chau Q; Zhang, Yun; Wells, James A

A general approach for selection of epitope-directed binders to proteins Journal Article

In: Proc Natl Acad Sci U S A, vol. 121, no. 19, pp. e2317307121, 2024, ISSN: 1091-6490.

Abstract | Links | BibTeX

A general approach for selection of epitope-directed binders to proteins
234 entries « 2 of 12 »
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