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2023

Conformation-specific Synthetic Antibodies Discriminate Multiple Functional States of the Ion Channel CorA., Erramilli, Satchal K., Dominik Pawel K., Deneka Dawid, Tokarz Piotr, Kim Sangwoo S., Reddy Bharat G., Skrobek Blazej M., Dalmas Olivier, Perozo Eduardo, and Kossiakoff Anthony A. , J Mol Biol, 2023 Jul 01, Volume 435, Issue 17, p.168192, (2023)

Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase., Bloch, Joël S., John Alan, Mao Runyu, Mukherjee Somnath, Boilevin Jérémy, Irobalieva Rossitza N., Darbre Tamis, Scott Nichollas E., Reymond Jean-Louis, Kossiakoff Anthony A., et al. , Nat Chem Biol, 2023 Jan 05, (2023)

2022

Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes., Orlando, Benjamin J., Dominik Pawel K., Roy Sourav, Ogbu Chinemerem P., Erramilli Satchal K., Kossiakoff Anthony A., and Vecchio Alex J. , J Biol Chem, 2022 Sep, Volume 298, Issue 9, p.102357, (2022)

Engineering of a synthetic antibody fragment for structural and functional studies of K+ channels., Rohaim, Ahmed, Slezak Tomasz, Koh Young Hoon, Blachowicz Lydia, Kossiakoff Anthony A., and Roux Benoît , J Gen Physiol, 2022 Apr 04, Volume 154, Issue 4, (2022)

Engineering of a synthetic antibody fragment for structural and functional studies of K+ channels., Rohaim, Ahmed, Slezak Tomasz, Koh Young Hoon, Blachowicz Lydia, Kossiakoff Anthony A., and Roux Benoît , J Gen Physiol, 2022 Apr 04, Volume 154, Issue 4, (2022)

Quaternary structure independent folding of voltage-gated ion channel pore domain subunits., Arrigoni, Cristina, Lolicato Marco, Shaya David, Rohaim Ahmed, Findeisen Felix, Fong Lam-Kiu, Colleran Claire M., Dominik Pawel, Kim Sangwoo S., Schuermann Jonathan P., et al. , Nat Struct Mol Biol, 2022 Jun, Volume 29, Issue 6, p.537-548, (2022)

Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers., Lim, Shion A., Zhou Jie, Martinko Alexander J., Wang Yung-Hua, Filippova Ekaterina V., Steri Veronica, Wang Donghui, Remesh Soumya G., Liu Jia, Hann Byron, et al. , J Clin Invest, 2022 Feb 15, Volume 132, Issue 4, (2022)

2021

Structure of an AMPK complex in an inactive, ATP-bound state., Yan, Yan, Mukherjee Somnath, Harikumar Kaleeckal G., Strutzenberg Timothy S., X Zhou Edward, Suino-Powell Kelly, Xu Ting-Hai, Sheldon Ryan D., Lamp Jared, Brunzelle Joseph S., et al. , Science, 2021 Jul 23, Volume 373, Issue 6553, p.413-419, (2021)

2020

Structure and mechanism of the ER-based glucosyltransferase ALG6., Bloch, Joël S., Pesciullesi Giorgio, Boilevin Jérémy, Nosol Kamil, Irobalieva Rossitza N., Darbre Tamis, Aebi Markus, Kossiakoff Anthony A., Reymond Jean-Louis, and Locher Kaspar P. , Nature, 03/2020, Volume 579, Issue 7799, p.443-447, (2020)

Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins., Mukherjee, Somnath, Erramilli Satchal K., Ammirati Mark, Alvarez Frances J. D., Fennell Kimberly F., Purdy Michael D., Skrobek Blazej M., Radziwon Katarzyna, Coukos John, Kang Yanyong, et al. , Nat Commun, March 27 2020, Volume 11, Issue 1, p.1598, (2020)

2019

Structure and drug resistance of the Plasmodium falciparum transporter PfCRT., Kim, Jonathan, Tan Yong Zi, Wicht Kathryn J., Erramilli Satchal K., Dhingra Satish K., Okombo John, Vendome Jeremie, Hagenah Laura M., Giacometti Sabrina I., Warren Audrey L., et al. , Nature, 2019 12, Volume 576, Issue 7786, p.315-320, (2019)

2018

Engineered synthetic antibodies as probes to quantify the energetic contributions of ligand binding to conformational changes in proteins., Mukherjee, Somnath, Griffin Dionne H., Horn James R., Rizk Shahir S., Nocula-Lugowska Malgorzata, Malmqvist Magnus, Kim Sangwoo S., and Kossiakoff Anthony A. , J Biol Chem, 2018 02 23, Volume 293, Issue 8, p.2815-2828, (2018)

Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination., Bailey, Lucas J., Sheehy Kimberly M., Dominik Pawel K., Liang Wenguang G., Rui Huan, Clark Michael, Jaskolowski Mateusz, Kim Yejoon, Deneka Dawid, Tang Wei-Jen, et al. , J Mol Biol, 2018 02 02, Volume 430, Issue 3, p.337-347, (2018)

The structure of the C-terminal domain of the nucleoprotein from the Bundibugyo strain of the Ebola virus in complex with a pan-specific synthetic Fab., Radwańska, Malwina J., Jaskółowski Mateusz, Davydova Elena, Derewenda Urszula, Miyake Tsuyoshi, Engel Daniel A., Kossiakoff Anthony A., and Derewenda Zygmunt S. , Acta Crystallogr D Struct Biol, 2018 07 01, Volume 74, Issue Pt 7, p.681-689, (2018)

2017

Prolactin Receptor-Mediated Internalization of Imaging Agents Detects Epithelial Ovarian Cancer with Enhanced Sensitivity and Specificity., Sundaram, Karthik M., Zhang Yilin, Mitra Anirban K., Kouadio Jean-Louis K., Gwin Katja, Kossiakoff Anthony A., Roman Brian B., Lengyel Ernst, and Piccirilli Joseph A. , Cancer Res, 2017 Apr 01, Volume 77, Issue 7, p.1684-1696, (2017)

Targeted rescue of cancer-associated IDH1 mutant activity using an engineered synthetic antibody., Rizk, Shahir S., Mukherjee Somnath, Koide Akiko, Koide Shohei, and Kossiakoff Anthony A. , Sci Rep, 2017 04 03, Volume 7, Issue 1, p.556, (2017)

2015

Architecture of the fungal nuclear pore inner ring complex., Stuwe, Tobias, Bley Christopher J., Thierbach Karsten, Petrovic Stefan, Schilbach Sandra, Mayo Daniel J., Perriches Thibaud, Rundlet Emily J., Jeon Young E., Collins Leslie N., et al. , Science, 2015 Oct 02, Volume 350, Issue 6256, p.56-64, (2015)

Assessment of a method to characterize antibody selectivity and specificity for use in immunoprecipitation., Marcon, Edyta, Jain Harshika, Bhattacharya Anandi, Guo Hongbo, Phanse Sadhna, Pu Shuye, Byram Gregory, Collins Ben C., Dowdell Evan, Fenner Maria, et al. , Nat Methods, 2015 Aug, Volume 12, Issue 8, p.725-31, (2015)

Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling, Rizk, S. S., Kouadio J. L., Szymborska A., Duguid E. M., Mukherjee S., Zheng J., Clevenger C. V., and Kossiakoff A. A. , Cell Commun Signal, 01/2015, Volume 13, Number 1, p.1, (2015)

Optimizing Production of Antigens and Fabs in the Context of Generating Recombinant Antibodies to Human Proteins., Zhong, Nan, Loppnau Peter, Seitova Alma, Ravichandran Mani, Fenner Maria, Jain Harshika, Bhattacharya Anandi, Hutchinson Ashley, Paduch Marcin, Lu Vincent, et al. , PLoS One, 2015, Volume 10, Issue 10, p.e0139695, (2015)

A switchable yeast display/secretion system., Van Deventer, James A., Kelly Ryan L., Rajan Saravanan, K Wittrup Dane, and Sidhu Sachdev S. , Protein Eng Des Sel, 2015 Oct, Volume 28, Issue 10, p.317-25, (2015)

2014

Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation, Marcon, E., Ni Z., Pu S., Turinsky A. L., Trimble S. S., Olsen J. B., Silverman-Gavrila R., Silverman-Gavrila L., Phanse S., Guo H., et al. , Cell Rep, Volume 8, Number 1, p.297-310, (2014)

Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain, Li, Q., Wanderling S., Paduch M., Medovoy D., Singharoy A., McGreevy R., Villalba-Galea C. A., Hulse R. E., Roux B., Schulten K., et al. , Nat Struct Mol Biol, Volume 21, Number 3, p.244-52, (2014)

Visualization of arrestin recruitment by a G-protein-coupled receptor, Shukla, A. K., Westfield G. H., Xiao K., Reis R. I., Huang L. Y., Tripathi-Shukla P., Qian J., Li S., Blanc A., Oleskie A. N., et al. , Nature, Volume 512, Number 7513, p.218-22, (2014)

2013

Generating conformation-specific synthetic antibodies to trap proteins in selected functional states, Paduch, M., Koide A., Uysal S., Rizk S. S., Koide S., and Kossiakoff A. A. , Methods, Volume 60, Number 1, p.3-14, (2013)

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