Publications
2023
Conformation-specific Synthetic Antibodies Discriminate Multiple Functional States of the Ion Channel CorA.,
Erramilli, Satchal K., Dominik Pawel K., Deneka Dawid, Tokarz Piotr, Kim Sangwoo S., Reddy Bharat G., Skrobek Blazej M., Dalmas Olivier, Perozo Eduardo, and Kossiakoff Anthony A.
, J Mol Biol, 2023 Jul 01, Volume 435, Issue 17, p.168192, (2023)
2021
Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.,
Bloch, Joël S., Mukherjee Somnath, Kowal Julia, Filippova Ekaterina V., Niederer Martina, Pardon Els, Steyaert Jan, Kossiakoff Anthony A., and Locher Kaspar P.
, Proc Natl Acad Sci U S A, 2021 Nov 23, Volume 118, Issue 47, (2021)
K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle.,
Yu, Yuanyuan, Zheng Qingyun, Erramilli Satchal K., Pan Man, Park Seongjin, Xie Yuan, Li Jingxian, Fei Jingyi, Kossiakoff Anthony A., Liu Lei, et al.
, Nat Chem Biol, 2021 Jul 08, (2021)
K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle.,
Yu, Yuanyuan, Zheng Qingyun, Erramilli Satchal K., Pan Man, Park Seongjin, Xie Yuan, Li Jingxian, Fei Jingyi, Kossiakoff Anthony A., Liu Lei, et al.
, Nat Chem Biol, 2021 Jul 08, (2021)
Structural basis of omega-3 fatty acid transport across the blood-brain barrier.,
Cater, Rosemary J., Chua Geok Lin, Erramilli Satchal K., Keener James E., Choy Brendon C., Tokarz Piotr, Chin Cheen Fei, Q Y Quek Debra, Kloss Brian, Pepe Joseph G., et al.
, Nature, 2021 Jun 16, (2021)
Structural basis of omega-3 fatty acid transport across the blood-brain barrier.,
Cater, Rosemary J., Chua Geok Lin, Erramilli Satchal K., Keener James E., Choy Brendon C., Tokarz Piotr, Chin Cheen Fei, Q Y Quek Debra, Kloss Brian, Pepe Joseph G., et al.
, Nature, 2021 Jun 16, (2021)
Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1.,
Chen, Qiuyan, Plasencia Manolo, Li Zhuang, Mukherjee Somnath, Patra Dhabaleswar, Chen Chun-Liang, Klose Thomas, Yao Xin-Qiu, Kossiakoff Anthony A., Chang Leifu, et al.
, Nature, 2021 Jul 14, (2021)
Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1.,
Chen, Qiuyan, Plasencia Manolo, Li Zhuang, Mukherjee Somnath, Patra Dhabaleswar, Chen Chun-Liang, Klose Thomas, Yao Xin-Qiu, Kossiakoff Anthony A., Chang Leifu, et al.
, Nature, 2021 Jul 14, (2021)
A T cell redirection platform for co-targeting dual antigens on solid tumors.,
Enderle, Leonie, Shalaby Karim H., Gorelik Maryna, Weiss Alexander, Blazer Levi L., Paduch Marcin, Cardarelli Lia, Kossiakoff Anthony, Adams Jarrett J., and Sidhu Sachdev S.
, MAbs, 2021 Jan-Dec, Volume 13, Issue 1, p.1933690, (2021)
2020
Recognition of an α-helical hairpin in P22 large terminase by a synthetic antibody fragment.,
Lokareddy, Ravi K., Ko Ying Hui, Hong Nathaniel, Doll Steven G., Paduch Marcin, Niederweis Michael, Kossiakoff Anthony A., and Cingolani Gino
, Acta Crystallogr D Struct Biol, September 1 2020, Volume 76, Issue Pt 9, p.876-888, (2020)
Structure and mechanism of the ER-based glucosyltransferase ALG6.,
Bloch, Joël S., Pesciullesi Giorgio, Boilevin Jérémy, Nosol Kamil, Irobalieva Rossitza N., Darbre Tamis, Aebi Markus, Kossiakoff Anthony A., Reymond Jean-Louis, and Locher Kaspar P.
, Nature, 03/2020, Volume 579, Issue 7799, p.443-447, (2020)
Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins.,
Mukherjee, Somnath, Erramilli Satchal K., Ammirati Mark, Alvarez Frances J. D., Fennell Kimberly F., Purdy Michael D., Skrobek Blazej M., Radziwon Katarzyna, Coukos John, Kang Yanyong, et al.
, Nat Commun, March 27 2020, Volume 11, Issue 1, p.1598, (2020)
2019
Structure and drug resistance of the Plasmodium falciparum transporter PfCRT.,
Kim, Jonathan, Tan Yong Zi, Wicht Kathryn J., Erramilli Satchal K., Dhingra Satish K., Okombo John, Vendome Jeremie, Hagenah Laura M., Giacometti Sabrina I., Warren Audrey L., et al.
, Nature, 2019 12, Volume 576, Issue 7786, p.315-320, (2019)
2018
Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.,
Zhang, Zhening, Liang Wenguang G., Bailey Lucas J., Tan Yong Zi, Wei Hui, Wang Andrew, Farcasanu Mara, Woods Virgil A., McCord Lauren A., Lee David, et al.
, Elife, 03/2018, Volume 7, (2018)
Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies.,
Pollock, Samuel B., Hu Amy, Mou Yun, Martinko Alexander J., Julien Olivier, Hornsby Michael, Ploder Lynda, Adams Jarrett J., Geng Huimin, Müschen Markus, et al.
, Proc Natl Acad Sci U S A, 2018 03 13, Volume 115, Issue 11, p.2836-2841, (2018)
Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies.,
Pollock, Samuel B., Hu Amy, Mou Yun, Martinko Alexander J., Julien Olivier, Hornsby Michael, Ploder Lynda, Adams Jarrett J., Geng Huimin, Müschen Markus, et al.
, Proc Natl Acad Sci U S A, 2018 03 13, Volume 115, Issue 11, p.2836-2841, (2018)
Structural basis for activation of SAGA histone acetyltransferase Gcn5 by partner subunit Ada2.,
Sun, Jian, Paduch Marcin, Kim Sang-Ah, Kramer Ryan M., Barrios Adam F., Lu Vincent, Luke Judy, Usatyuk Svitlana, Kossiakoff Anthony A., and Tan Song
, Proc Natl Acad Sci U S A, 2018 10 02, Volume 115, Issue 40, p.10010-10015, (2018)
2017
Generating Conformation and Complex-Specific Synthetic Antibodies.,
Paduch, Marcin, and Kossiakoff Anthony A.
, Methods Mol Biol, 2017, Volume 1575, p.93-119, (2017)
Prolactin Receptor-Mediated Internalization of Imaging Agents Detects Epithelial Ovarian Cancer with Enhanced Sensitivity and Specificity.,
Sundaram, Karthik M., Zhang Yilin, Mitra Anirban K., Kouadio Jean-Louis K., Gwin Katja, Kossiakoff Anthony A., Roman Brian B., Lengyel Ernst, and Piccirilli Joseph A.
, Cancer Res, 2017 Apr 01, Volume 77, Issue 7, p.1684-1696, (2017)
2016
Conformational Chaperones for Structural Studies of Membrane Proteins Using Antibody Phage Display with Nanodiscs.,
Dominik, Pawel K., Borowska Marta T., Dalmas Olivier, Kim Sangwoo S., Perozo Eduardo, Keenan Robert J., and Kossiakoff Anthony A.
, Structure, 2016 Feb 02, Volume 24, Issue 2, p.300-9, (2016)
Determination of equilibrium dissociation constants for recombinant antibodies by high-throughput affinity electrophoresis.,
Pan, Yuchen, Sackmann Eric K., Wypisniak Karolina, Hornsby Michael, Datwani Sammy S., and Herr Amy E.
, Sci Rep, 2016 Dec 23, Volume 6, p.39774, (2016)
Direct Proximity Tagging of Small Molecule Protein Targets Using an Engineered NEDD8 Ligase.,
Hill, Zachary B., Pollock Samuel B., Zhuang Min, and Wells James A.
, J Am Chem Soc, 2016 Oct 12, Volume 138, Issue 40, p.13123-13126, (2016)
Specific Recognition of a Single-Stranded RNA Sequence by a Synthetic Antibody Fragment.,
Shao, Yaming, Huang Hao, Qin Daoming, Li Nan-Sheng, Koide Akiko, Staley Jonathan P., Koide Shohei, Kossiakoff Anthony A., and Piccirilli Joseph A.
, J Mol Biol, 2016 10 09, Volume 428, Issue 20, p.4100-4114, (2016)
2015
Architecture of the fungal nuclear pore inner ring complex.,
Stuwe, Tobias, Bley Christopher J., Thierbach Karsten, Petrovic Stefan, Schilbach Sandra, Mayo Daniel J., Perriches Thibaud, Rundlet Emily J., Jeon Young E., Collins Leslie N., et al.
, Science, 2015 Oct 02, Volume 350, Issue 6256, p.56-64, (2015)
Architecture of the fungal nuclear pore inner ring complex.,
Stuwe, Tobias, Bley Christopher J., Thierbach Karsten, Petrovic Stefan, Schilbach Sandra, Mayo Daniel J., Perriches Thibaud, Rundlet Emily J., Jeon Young E., Collins Leslie N., et al.
, Science, 2015 Oct 02, Volume 350, Issue 6256, p.56-64, (2015)
Pages
Publications
- Characterization of synthetic antigen binding fragments targeting Toc75 for the isolation of TOC in A. thaliana and P. sativum.
- Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
- Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes.
- Engineering of a synthetic antibody fragment for structural and functional studies of K+ channels.
- Isoform- and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder.
- Quaternary structure independent folding of voltage-gated ion channel pore domain subunits.
- Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
- Structure of an AMPK complex in an inactive, ATP-bound state.
- Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver.
- Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase.
- Structures of ABCB4 provide insight into phosphatidylcholine translocation.
- Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.
- Synthetic Antibodies Detect Distinct Cellular States of Chromosome Passenger Complex Proteins.
- Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers.