Publications
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Structural Modeling of Human Growth Hormone Receptor using Computational Simulations and NMR Spectroscopy,
Rui, H., Kossiakoff A., and Im W.
, Biophys J, Volume 104, Number 2, Supplement 1, p.117a-118a, (2013)
Engineering of a synthetic antibody fragment for structural and functional studies of K+ channels.,
Rohaim, Ahmed, Slezak Tomasz, Koh Young Hoon, Blachowicz Lydia, Kossiakoff Anthony A., and Roux Benoît
, J Gen Physiol, 2022 Apr 04, Volume 154, Issue 4, (2022)
Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling,
Rizk, S. S., Kouadio J. L., Szymborska A., Duguid E. M., Mukherjee S., Zheng J., Clevenger C. V., and Kossiakoff A. A.
, Cell Commun Signal, 01/2015, Volume 13, Number 1, p.1, (2015)
Substance P derivatives as versatile tools for specific delivery of various types of biomolecular cargo,
Rizk, S. S., Misiura A., Paduch M., and Kossiakoff A. A.
, Bioconjug Chem, Volume 23, Number 1, p.42-6, (2012)
Targeted rescue of cancer-associated IDH1 mutant activity using an engineered synthetic antibody.,
Rizk, Shahir S., Mukherjee Somnath, Koide Akiko, Koide Shohei, and Kossiakoff Anthony A.
, Sci Rep, 2017 04 03, Volume 7, Issue 1, p.556, (2017)
The structure of the C-terminal domain of the nucleoprotein from the Bundibugyo strain of the Ebola virus in complex with a pan-specific synthetic Fab.,
Radwańska, Malwina J., Jaskółowski Mateusz, Davydova Elena, Derewenda Urszula, Miyake Tsuyoshi, Engel Daniel A., Kossiakoff Anthony A., and Derewenda Zygmunt S.
, Acta Crystallogr D Struct Biol, 2018 07 01, Volume 74, Issue Pt 7, p.681-689, (2018)
Publications
- Characterization of synthetic antigen binding fragments targeting Toc75 for the isolation of TOC in A. thaliana and P. sativum.
- Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
- Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes.
- Engineering of a synthetic antibody fragment for structural and functional studies of K+ channels.
- Isoform- and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder.
- Quaternary structure independent folding of voltage-gated ion channel pore domain subunits.
- Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
- Structure of an AMPK complex in an inactive, ATP-bound state.
- Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver.
- Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase.
- Structures of ABCB4 provide insight into phosphatidylcholine translocation.
- Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.
- Synthetic Antibodies Detect Distinct Cellular States of Chromosome Passenger Complex Proteins.
- Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers.